PEG MGF 4 mg

• PEG-MGF 4 mg — Sterling Knight Pharmaceuticals
• Category: Peptide / IGF-1Ec Analog (PEGylated)
• Brand: Sterling Knight Pharmaceuticals
• Strength: 4 mg lyophilised peptide
• Form: Sterile vial for reconstitution
• Packing: 1 vial
• Origin: United Kingdom
• Research Use: Laboratory and analytical use only. Not for human or veterinary use.

What Is PEG-MGF?

PEG-MGF is a PEGylated analogue of Mechano Growth Factor (MGF), which is the E-domain splice variant of IGF-1Ec. Native MGF is short-lived in circulation; PEGylation significantly extends its duration, enabling researchers to study regeneration, repair, and mechanotransduction pathways with improved stability.

• Derived from the IGF-1Ec splice variant
• PEG-conjugation improves half-life and systemic exposure
• Useful in muscle-repair and satellite-cell activation models
• Supplied as a 4 mg lyophilised vial

Key Research Highlights

1. Biology & Origin

MGF (IGF-1Ec) is produced via alternative splicing of the IGF-1 gene and is typically upregulated following mechanical loading, muscle injury, and tissue damage. Its E-domain is biologically distinct from IGF-1Ea.

2. Preclinical Findings

Studies associate MGF E-peptide with:

• Satellite-cell activation
• Myoblast differentiation
• Regeneration signalling

Evidence varies — some studies support distinct activity, while others show limited effects for synthetic fragments.

3. Why PEGylate?

• Greatly increases peptide half-life
• Provides extended bioavailability
• Enables longer sampling windows in PK/PD studies
• Common technique for stabilizing otherwise short-lived peptides

4. Anti-Doping Relevance

MGF analogues, IGF-1 analogues, and growth-factor mimetics are banned under WADA S2.

Research Applications

• Muscle-repair and regeneration signalling models
• Time-course experiments requiring prolonged peptide exposure
• Satellite-cell activation studies
• Anti-doping reference development for IGF/MGF-class agents

Potential Side Effects & Class-Based Risks

As a growth-factor mimic, PEG-MGF may influence:

• Endocrine pathways
• Cellular proliferation/repair signalling
• Metabolic responses related to IGF-axis activation

Exposure may result in a positive WADA S2 doping test. Handle using appropriate biosafety precautions and personal protective equipment.

Compliance & Handling

• FOR RESEARCH USE ONLY — not for human consumption
• Not a dietary supplement or medical product
• Use only by trained laboratory personnel
• Follow institutional SOPs, SDS guidelines, and proper disposal
• WADA Category: S2 — Peptide hormones & growth factors

Scientific Data Table

Field

Data

Chemical Name

PEGylated Mechano Growth Factor (PEG-MGF), PEG conjugate of IGF-1Ec E-domain

Chemical Formula

Variable (PEGylated conjugates depend on PEG chain length)

Synonyms

PEG-MGF; PEG-IGF-1Ec; PEG-Mechano Growth Factor

Molecular Weight

Variable; commonly ~20–30 kDa depending on PEG size (confirm via COA)

CAS Number

No universal CAS; depends on manufacturer and PEG length

Scientific Notes

IGF-1Ec/MGF induced by mechanical stress; PEGylation extends half-life substantially; mixed evidence on synthetic fragment potency

Total Content

4 mg lyophilised peptide

Storage

Store per label; protect from light; typical unopened stability 24–36 months

Origin

United Kingdom

Intended Use

Laboratory research and analytical method development only

Research chemical — not for human or veterinary use.